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I had Botox for the first time with an experienced dermatologist. It didn’t work so we did two top-ups, which also didn’t work. Then we tried two different brands but also didn’t work. Seems like I have antibodies. Any tips about where to go now?

By Priyanka Rai
11th April 2022

It sounds like you are resistant to the drug, but this is really quite rare. Manufacturer clinical trials showed that no more than 1.5% of patients develop “neutralising antibodies”, and the figures are something like 1 in 10,000 that it doesn’t work for. Usually, if the treatment doesn’t work, it can be because of the dosage (not everyone’s the same, and some people need a higher dose) or the dilution of the product. But you say the practitioner was an experienced dermatologist.

It’s hard to tell if you had all the treatments at the same clinic. It may be worth getting a second opinion, but you could be wasting your money if you are resistant. I am not a big fan of lotions and potions that promise they give the same results as Botox. They don’t. One thing you could try is the Dr Steve Harris Anti-Wrinkle Sleep Mask. 

 

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