Tweakment Finder TWEAKMENT




Written by: Becki Murray

Updated by:

Reviewed by: Alice Hart-Davis

Last Updated: 9 April 2024

REFYNE is one of the dermal fillers in Galderma’s Restylane brand, a pioneer and leader in hyaluronic acid (HA) filler technology. REFYNE features Galderma’s trademarked Optimal Balance Technology (OBT), a process of cross-linking hyaluronic acid molecules to produce fillers that deliver exactly the degrees of firmness, elasticity, and longevity needed for specific facial filling needs.


REFYNE is a soft and flexible filler designed for treating dynamic areas of your face — areas that experience significant amounts of movement during everyday actions such as smiling, talking, and eating. These include the area around your lips and the areas through which your nose-to-mouth lines and ‘marionette’ lines run.

Price Range

Around £250 upward for 1ml of REFYNE


Cross-linked hyaluronic acid filler for dynamic areas of your face


Reduces lines and moderate wrinkles while retaining natural movement

Lasts for

18 months with one re-treatment

Treatment Time

15 to 45 minutes

Any Anaesthesia

Contains lidocaine



Why We Recommend Restylane Refyne

Alice Hart-Davis
Founder, The Tweakments Guide

Fine lines and wrinkles in your face can quickly make you look older than you are and much older than you feel. Dermal fillers can reduce wrinkles and erase fine lines, but you need to make sure you get the right filler for each area of your face. REFYNE from Restylane is fantastic for minimising wrinkles and fine lines while keeping your full range of facial movement and your natural expression

About Restylane Refyne

Why might you be interested in REFYNE?

You might be interested in REFYNE if your face has developed mild to moderate lines and wrinkles that you want to minimise. REFYNE’s softness and flexibility enable the practitioner to deliver subtle and natural-looking results.

If you have deeper lines and wrinkles, consider treatment with Restylane DEFYNE rather than REFYNE. DEFYNE is a filler with a firmer consistency than REFYNE, so DEFYNE can provide stronger lift and support than REFYNE can.

How does a REFYNE treatment work?

Before the treatment, you meet with the practitioner so they can examine your facial structure, learn your medical history and your aesthetic goals, and agree a treatment plan with you.

For the treatment, the practitioner cleanses your skin thoroughly, and then injects REFYNE into the treatment area or areas using either a fine needle or a cannula (a thin, flexible tube). After injecting the filler, the practitioner may massage the area to distribute and shape the filler as needed.

How long do the results last?

REFYNE lasts for up to 18 months with one re-treatment.

Is treatment with REFYNE painful?

No. Treatment with REFYNE is not painful, but you may experience mild discomfort from the injections. Most formulations of REFYNE include lidocaine, a local anaesthetic, to alleviate any discomfort. Confirm with your practitioner that the REFYNE they will use includes lidocaine; if not, you can ask the practitioner to numb the treatment areas beforehand with another form of anaesthetic, such as a numbing cream. If you are concerned about the injections hurting, ask your practitioner to numb the treatment areas beforehand.

Where can REFYNE be used?

REFYNE is typically used to treat mild to moderate lines and wrinkles on your face:

  • Nose-to-mouth lines. These lines, known in the trade as ‘nasolabial lines’, run down from the sides of your nose to the corners of your mouth.
  • Lines around your mouth. These lines, which practitioners sometimes refer to as ‘perioral lines’, develop as a result of aging; smiling, laughing, and making expressions; and other factors.
  • Marionette lines. These are the lines that run down from each corner of your mouth to your chin.

How long does REFYNE treatment take?

A treatment with REFYNE typically takes between 15 and 45 minutes, depending on which and how many facial areas you’re having treated.

In some cases, you may need a touch-up treatment a couple of weeks after the initial treatment to give you optimum results.

To maintain your treatment results in the long term, you may want to have a top-up treatment or re-treatment. These treatments would typically use smaller amounts of REFYNE filler — just enough to restore any volume the treatment areas have lost. Consult your practitioner about such top-up treatments and when to have them.

How quickly can you see results from REFYNE treatment?

You will see an immediate effect from REFYNE treatment, because the contours of your face will change from having the filler injected. As any swelling from the injections decreases and the filler settles in your face, you will see the results more clearly.

At what age can you get REFYNE treatment?

You can get REFYNE treatment from the age of 18 in the UK.

How much does a REFYNE treatment cost?

The cost of a REFYNE treatment varies depending on the amount of filler required and the geographical location in which you’re having the treatment. Typical prices start at £250 for a treatment that uses 1ml of REFYNE.

Will I have scars from REFYNE treatment?

No. REFYNE is a noninvasive treatment and causes no scars.

Are there side-effects from REFYNE treatment?

REFYNE treatment has minimal downtime and modest side effects. Most patients are able to resume their normal activity the same day, so if you have a lunchtime appointment, you could go back to work that afternoon.

You may experience some redness, swelling, tenderness, or bruising in the area treated. These side effects will usually disappear within a week; if not, consult your practitioner for advice.

What is the aftercare advice following a REFYNE treatment?

After having REFYNE injections, be gentle with the treatment areas, and apply concealer as needed:

  • Give the treatment areas time to settle down rather than applying make-up to them immediately.
  • About 24 hours after the treatment, you can apply a light cover-up if needed.
  • If you have remaining redness, try a concealer with a slight green or yellow tone. If you have bruising, try a yellow-toned concealer.

Your practitioner may also advise you to avoid vigorous exercise for the first few days after having REFYNE injections.

Who makes REFYNE?

REFYNE is manufactured and marketed by Galderma, a pharmaceutical company with a worldwide presence and more that 6,000 employees. REFYNE is part of Galderma’s Restylane brand of hyaluronic acid fillers, which also includes Restylane LYFT, Restylane DEFYNE, and Restylane KYSSE. Restylane specialises in HA fillers close in composition to your skin’s own HA and is a highly trusted brand, with more than 65 million treatments delivered worldwide.

Who are dermal fillers not suitable for?

Dermal fillers, such as REFYNE, are not suitable for the following people with the following conditions:

  • Pregnancy or breastfeeding. Avoid having dermal fillers while you are pregnant or breastfeeding.
  • Younger than 18. Dermal fillers are generally not recommended if your body is still growing.
  • Active skin infections. Clear up any active skin infections, such as acne or cold sores, before having dermal fillers.
  • Autoimmune diseases. These diseases generally preclude the use of dermal fillers.
  • Using medication that affects bleeding. If you are taking nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, or other medication that affects bleeding, discuss it with your practitioner.

You should also ask your practitioner about any other conditions that may make you unsuitable for treatment with REFYNE.

What is Restylane Refyne used to treat


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